Research

Our main research field are optical sensors, where we use both label-free detection methods such as RIfS (Reflectometric Interference Spectroscopy), SPR (Surface Plasmon Resonance), MZI (Mach-Zehnder Interferometer), and integrated optical grating couplers (these methods are employed in biomolecular interaction analysis and chemical sensors), and optical methods using fluorescence labels such as TIRF (Total Internal Reflection Fluorescence) or FRET (Förster Resonance Energy Transfer). Besides common organic fluorophores, we synthesize specially designed quantum dots (QDs) wich exhibit better properties than fluorescence labels.

The chip surfaces modified using chemical or photochemical reactions are subjected to various analysis methods such as spectral or monochromatic ellipsometry, AFM (Atomic Force Microscopy), contact angle measurements etc. Surface characterisation is therefore the second important field of activity in our group.

Optical spectroscopy and surface characterization are complemented by calorimetric methods used in biomolecular interaction analysis.

Chemometrics simplifies the evaluation of substance and system properties which are difficult to measure directly.