Projects

Current Projects

Name Description Financial Support
Papierbasierte Low Cost Sensorik - Von der Mikrofabrikation bis zur EvaluationThe aim of the project is the quantitative detection of salmonellae and C-reactive protein, by using microfluidic paper-based analytical devices (µPADs). Thereby, a parallelized analysis for different types of salmonellae is to be developed. The detection antibodies are labeled with gold nanoparticles so that signals can be read out from integrated cameras in smartphones. For investigating the influence of labeling to interactions between antibodies and antigens the Reflectometric Interference Spectroscopy (RIfS) is used.BMWi

Former Projects

Name Description Financial Support
ACUTLABThe Project ACUTLAB is funded by the German Federal Ministry of Economics and Technology. The executing organization is the F.O.M. Forschungsvereinigung Feinmechanik, Optik und Medizintechnik e.V. ACUTLAB will provide a portable, robust and easily to handle medical diagnostic Point-of-Care (POC) Testing device with networking capability. Fields of applications will be the full quantitative detection of organ specific parameters for kidney function and pancreas diagnostic such as cystatin C and lipase. This is of special interest due to the fact that these parameters have not yet been available on POCT devices.
During this project assays for the specified parameters will be developed for measurements in serum and blood plasma. The main focus will be the handling of unspecific binding in the complex matrices and integration of the assays into the device.
At the end of the project a small, flexible, low cost diagnostic device designed for multiparametric measurements will be delivered.

Final Report
Flyer Innovationstag
Poster AG Gauglitz
Poster UKT

BMWi
AquaTerraIntegrated modelling of the river-sediment-soil-groundwater system; advanced tools for the management of catchment areas and river basins in the context of global changeEU
AWACSSA network of automated analytical systems for measuring multiple analytes in river waterEU
BBMOBiosensor based on molecular organizationEU
Biomimetischer ProzesssensorThe project aims for establishing biomimetic recognition structures as sensitive layer for optical sensors. Molecularly imprinted polymer nanoparticles will be modified with different anchor groups which enable for a covalent immobilization onto sensor surfaces without affecting the MIPs' binding properties. The obtained stability of the sensor surfaces allow for measurements under adverse conditions like high temperatures and extreme pH values. Results obtained with this modelsystem will be used to evaluate possible applications of MIPs in process analytics. MWK
BioMIPThe BIOMIP project aims to develop a sensor for in-line process monitoring of fermentation processes. Hereby the sensor will be installed inside the process reactor with the possibility to read out the sensor from outside. To achieve these aims, sensitive layers based on molecularly imprinted nanospheres (nanoMIPs) will be developed. These sensitive layers will be sterilizable and thus it is possible to integrate them into ferment. The interaction of the sensitive layers with the analyte will be read out using 1-λ-Reflectometric interference sensing (1-λ-RIfS). This technique allows for a non-contact readout from outside the ferment. Thus an effective and accurate process analytic will be realized. Landesministerium für Wissenschaft, Forschung und Kunst, Baden-Württemberg
CARE-MANDevelopment of a validated, intelligent, fully automated diagnostic device on a modular technology platform, combining successful transduction principles, biochemical recognition methods and communication capabilities for a multi parameter measurement characterising diseases defined by doctors and needs in hospitals.EU
CASCADEChemicals as contaminants in the food chain - a network of excellence for research, risk assessment and educationEU
GenSensor - NanopartsNano-biotechnical components of an advanced bioanalytical microarray systemEU
GRIN-SENThe project GRIN-SEN aims to develop an optical hybrid system consisting of gradient-index (GRIN) optics and plasmonic nanostructures/ optical micro resonators, which can be used in the field of sensors. Both in clinical diagnostics and environmental analysis the need for portable, robust and easy to handle devices has grown enormously. The key feature of this approach is the label-free ultrasensitive detection of single molecules or particles with no need of complex optical laboratory systems. During this project assays for detection of H1N1 viruses (as example in the field of clinical diagnostics), Endocrine Disrupting Chemicals (EDCs) and analgesics (as examples of environmental analysis) will be developed and established by the research group Gauglitz.Landesministerium für Wissenschaft, Forschung und Kunst, Baden-Württemberg
INSTANTINSTANT started within the EU-Call FP7-NMP.2011.1.3-1 on March 1st and will face the challenge of the detection, identification and quantification of engineered nanoparticles (ENPs) in complex matrices. 5 SMEs together with 3 universities and the BAM will develop an innovative, cost effective, and easy to use analytical tool to extract, detect and identify ENPs typically used in cosmetic products (e.g. sunscreen, toothpaste, deodorant, ...) and engineered food (e.g. instant soups, ketchup, ice cream, ...) and drinks (e.g. fruit juice, energy drinks, bottled water, ...). studies. In the focus are recently emerging ENPs like Ag, SiO2, TiO2, ZnO, and organic NPs. They monitor the exposure of consumers to ENPs using a label free opto-electrochemical sensor array in combination with novel recognition elements like molecular imprinted polymers or nanotubes.EU
KW-InlineTimeresolved in-line detection of hydrocarbons with fiberoptical chemosensorsBMFT
Landesforschungs- schwerpunktMWK
LIBRARIANSearch for pharmaceutical leads using label free detection methodsBMFT
LINDAUImmuno-analytics on a chipBMBF
Markierungsfreie Hochdurchsatzsuche von PeptidbibliothekenDevelopment of a HTS-detection platform by combining the parallelized reflectometric interference spectroscopy (iRIfS) and freely scalable high-density peptide libraries. These high-density peptide libraries will be generated by combinatorial peptide synthesis. The project is focused on screening for therapeutically interesting peptides.Landesstiftung
MENDOSMolecular imprinted polymers for Environmental Endocrine Disruptor Screening with optical sensorsEU
MF-HTSLabel-free High Throughput Screening of protein-ligand interactionsfor clinical diagnostics AIF
MOBAmicrooptical excitation-/sensorelement for biochip analysisBMBF
MoDekt

Modular platform for label free, direct optical bioanalysis

This project works on modern photo detector inventions for bioanalytical procedures and their integration in a modular detection platform that has different demands on molecular analytics in medicine and diagnostics. It is highly configurable and scalable. Evaluation is done by using the direct optical and label free procedure (RIfS) within a large university clinic.

BMBF
MPUmonitoring of biotechnical production for a processintegrated pollution controlBundesstiftung Umwelt
Nanobioanalytik mit On-Chip IR Mach-Zehnder InterferometernWithin the 'network of competence' of the Federal State Baden Wuerttemberg a joint project is performed with the Institute of Analytical and Bioanalytical Chemistry of the University of Ulm. Aim of the project is a kind of nano-scale analysis regarding structural dimensions, detection area, required reagents, and analyte concentrations. The experiments will help to understand interaction processes in molecular dimensions. Traces of estrogens will be detected and identified by combination of Mach-Zehnder chips operating in the mid-infrared region and selective structures.BW Stifung, MWK
NANODEMA great risk after organ tranplantation is rejection. For this reason it is important to monitor the immunosuppressant blood level frequently for calculation of the next dosage. At the moment blood levels are controlled in maximum hourly or less often. A new device will be created, which will measure the concentrations of immunosuppressive drugs with a very high frequency between 5 and 20 min time intervals. The microfluidic chip, containing the immunoassay procedure, is connected to the patients' central venous catheter via a micro dialysis unit. Analyte antibody interaction will be detected by fluorescence measurements. The usage of magnetic and fluorescent nanoparticles will improve detection limits of the drugs.EU
nanoMAPModular Application Platform with Integrated Nanoliter Dosage for Highly Parallel Sample AnalysisBMBF
OSYRISSimultaneous discrimination of refrigerantsAIF
PepperThis project works on scientific basic principles and prototyping of a miniaturized Point-of-Care sensor based on direct optical detection for simple and low-cost multi parameter detection of analytes of clinical relevance. The core of this project is on the one hand the deployment of a microfluidics system designed as disposable cartridge and on the other hand the system integration with a chip-based optical sensor system to generate a user friendly prototype. In this way different areas of microsystems technology are used and integrated. Aim is to construct an assembly that extends the usual academically inventions of laboratory patterns to demonstrate industry an economical usage.BMBF
PIWASparallelized immunoreaktionbased water-analyzer-systemBMBF
Promotionsverbund -Bakterien-Material-Wechselwirkungen-The study of bacterial and molecular interaction on surfaces, occurring e.g. during initial biofilm formation and changes in material surface properties caused by microbacterial activities, is complex and requires a coordinated interdisciplinary approach. The goal of this interdisciplinary network for the promotion of graduate students is to jointly develop and enhance an interdisciplinary research and teaching concept based on various methodical approaches. The close cooperation of recognized natural scientists from various areas and medical scientists will help to find new ways of addressing basic issues in this field.
Reactions in Porous mediaAnalysis and modelling of diffusion/dispersion-limited Reactions in porous mediaDFG
RESCheckThe Res(piratory)Check Project is funded by the BMBF. The research group Gauglitz develops immunoassays for markers of respiratory infections in this project. The aim of the project is to establish a fast peripheral detection system of bacterious and viral respiratory infections. Together with 9 partners from industry, agency and universtiy the project is conducted.BMBF
RIANAAn analytical system for measuring analytes in river waterEU
Steinbeis-Transferzentrum: Optische Chemo- und Biosensoren
TierdiagnostikDevelopment of a low cost, miniaturized platform for antibody based, label-free, parallel assessment of several parameters for animal diagnosticsAIF
WamazinDevelopment of an effect-directed-based analytical device using the natural interaction of plant D1-protein with herbicides. To fulfill the requirements for low limits of detection a novel Mach-Zehnder Interferometer system will be developed accordingly.BMBI